Develop tools such as vaccine platforms and expression systems immunological toolboxes and delivery system
SOA
21
Internal project
Action 2 - Leading Institute: DTU
Project summary
Prevention is better than cure, and vaccine based disease prophylaxis represents a key element in sustainable animal farming with high animal health and welfare. For a range of infectious diseases in farmed animals, vaccines are either not available or insufficient. This project aims at developing/improving/consolidating a range of new vaccine technologies along with tools to evaluate/predict protective efficacy of vaccines for use in animal husbandry including aquaculture.
Project objectives
- Identify and improve vaccine antigens
- Implement vaccine platforms such as:
- Nano and microparticle based vaccines
- Nucleic acid vaccines
- Extracellular vesicle and yeast based vaccines
- Viral vector and reverse genetic vaccines
- Mycoplasma based vaccines
- Develop, improve and evaluate delivery strategies, adjuvants and formulations for vaccines
- Develop tools to evaluate the host response to vaccine and vaccine adjuvants including:
- Tools to characterize protective immune response
- In vitro immune assays for monitoring host immune response to vaccination
- Profiling bioinformatics to identify immune signatures of potent vaccines
- Assays correlating with vaccine-induced immunity and vaccine efficacy.
- Develop tools for studying interaction between bacterial vector vaccines and gut microbiota.
Outcomes and impacts
- New and improved veterinary vaccines and vaccine adjuvants
- New tools for evaluation and monitoring vaccine induced immune responses and correlates of protection
- Tools for future improved disease prophylaxis in farmed animal, which will contribute to improved animal welfare, sustainable animal production and green transition.