Host pathogen environment interaction network
SOA
32
Internal project
HEPINET- Host-Pathogen-Environment Interaction Network THE PROJECT'S WORK IS SUBJECTED TO REA'S APPROVAL OF THE AMENDMENT TO THE EUPAHW GRANT AGREEMENT 101136346
Action 6 - Leading Institute: INRAE
Project summary
HEPINET will focus on the study of host-pathogen-environment interactions. Species considered are ruminants, pigs, poultry and aquatic species and wildlife animals.
The pathobiome will be explored in different contexts/conditions/environments to understand its dynamics. Adaptation of pathogens to their environment, and the molecular mechanisms involved, will be investigated along with the environmental factors that may influence this adaptation.
Project objectives
The general objectives of this project will be:
- To describe host-pathogen-environment interactions in relevant species and evaluate the environmental biotic and abiotic factors
- To characterize the dynamics driving interactions between host, pathogen, and the environment.
- To identify virulence and antimicrobial resistance markers and drivers of dissemination affecting pathogen emergence, adaptation, and persistence in production systems.
- To characterize the host/vector pathobiome and its interactions with host/vector characteristics
- To investigate how pathogens adapt to different environments and identify environmental drivers that modulate disease prevalence
- Ultimately, to apply a community ecology framework to investigate how microbial and pathogen communities are structured and shaped by both biotic (e.g., host genotype, infection status) and abiotic (e.g., temperature, antimicrobials, micro/nanoplastics) factors.
Outcomes and impacts
Outcomes:
- a holistic perspective on disease mechanisms and on how environmental variables modulate the pathogen-host axis
- rational bases for the design of prevention and intervention strategies based on microbiome modulation
- data on how environmental variables modulate the pathogen-host axis
- identify the danger of MNPs in animal health
- better understanding of pathogen adaptation, infection dynamics, and coinfection effects,
- insights into the impact of environmental and climatic conditions on the total vectors microbial ecosystem
- rapid and harmonized methods for early pathogen detection
- pipeline for microbial ecosystem characterization
Impact:
- Enhanced disease control strategies and management
- Development of new/improved pathogen control, detection and monitoring methods
- Improved risk assessment of emerging strains and enhanced surveillance
- Advancements in microbiome research
- Reduced transmission of vector-borne diseases
- Reduction in antimicrobial usage
- Guidance to farmers and other key stakeholders on improved biosecurity measures
Priority Area 2
Procedures, methodologies and tools to analyse animal health and welfareOperational objective (OO3)
To develop diagnostic procedures, methodologies and tools to support the surveillance of animal health
ACRONYM: HEPINET