Project 4
SOA
28
Internal project
Risk of spread of AMR and associated genes in veterinary pathogens - THE PROJECT'S WORK IS SUBJECTED TO REA'S APPROVAL OF THE AMENDMENT TO THE EUPAHW GRANT AGREEMENT 101136346
Action 4 - Leading Institute: DTU
Project summary
This project investigates how antimicrobial resistance genes (ARGs) emerge, spread and persist in veterinary pathogens in livestock. By combining genomic analyses, epidemiological studies, and laboratory experiments, the project will identify drivers of AMR dissemination and provide evidence useful in risk assessment that supports surveillance and risk mitigation.
Project objectives
- Identify antimicrobial resistance genes (ARGs) and mobile genetic elements in veterinary pathogens from cattle, pigs, poultry, fish and horses using existing and newly generated whole genome sequence data.
- Assess how antimicrobial use, farm management, disinfectants, metals and other production factors influence the emergence and spread of AMR.
- Investigate horizontal gene transfer mechanisms and factors affecting ARG transmission using experimental in vitro models.
- Generate knowledge to strengthen qualitative AMR risk assessment and support evidence-based mitigation strategies.
- Develop harmonised methodologies, training activities and workshops to build European capacity in AMR risk assessment.
Outcomes and impacts
- Improved understanding of the occurrence, transmission and persistence of antimicrobial resistance genes in veterinary pathogens.
- Identification of key risk factors driving AMR emergence and dissemination in livestock production systems.
- New knowledge on horizontal gene transfer and the role of mobile genetic elements.
- Harmonised genomic datasets, analytical methods and experimental protocols for European collaboration.
- Scientific publications, workshops, training activities and strengthened collaboration between European research organisations.
- Evidence supporting future surveillance, prevention and policy initiatives within a One Health framework.
Priority Area 1
Surveillance / monitoring systems and risk assessment for animal health and welfareOperational objective (OO2)
Contribute to adapt risk assessment and alert communication to the new needs in animal health and welfare